Thermo Fisher Scientific PSME2 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Predicted to react with canine, mouse, and rat based on sequence homology.
• Tested in Peptide ELISA: antibody detection limit dilution 1:32,000.

Target Information

Proteolytic degradation maintains appropriate levels of short-lived and regulatory proteins involved in cellular metabolism, stress response, antigen presentation, receptor modulation, cell cycle regulation, transcription, and signaling.
The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cytosol and nucleus, while others are degraded via the vacuolar pathway (endosomes, lysosomes, ER).
The 26S proteasome is an ATP-dependent, multisubunit (~31) complex (~2.5 MDa) consisting of a 20S proteolytic core and one or two 19S regulatory subunits.
The 19S subunits recognize ubiquitinated proteins and facilitate their unfolding and translocation into the 20S core.
Defects in this pathway are linked to genetic diseases such as cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.