Thermo Fisher Scientific PSME1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.3–1 µg/mL

Product Specifications

Product Specific Information

• This antibody is predicted to react with canine, mouse, and rat based on sequence homology.
• Tested in Peptide ELISA: antibody detection limit dilution 64,000.

Target Information

Proteolytic degradation is essential for maintaining appropriate levels of short-lived and regulatory proteins involved in diverse cellular processes such as metabolism, stress response, antigen presentation, receptor modulation, cell cycle regulation, and transcriptional signaling.

The ubiquitin-proteasome pathway is responsible for degrading most cytosolic and nuclear proteins in eukaryotic cells. The 26S proteasome, an ATP-dependent multisubunit complex (~2.5 MDa), consists of a 20S proteolytic core and one or two 19S regulatory subunits. The 19S subunits recognize ubiquitinated proteins, unfold them, and translocate them into the 20S core for degradation.

Defects in the ubiquitin-proteasome pathway are linked to several genetic diseases, including cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.