Thermo Fisher Scientific Nucleophosmin Monoclonal Antibody (NPM1, 1902)
Nucleophosmin 단백질(NPM1)을 인식하는 Thermo Fisher Scientific의 mouse monoclonal 항체. Western blot, IHC, ICC/IF 등 다양한 응용에 적합. 단백질 A/G로 정제된 액상 항체로, 4°C에서 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | NPM1, 1902 |
| Immunogen | Recombinant fragment (around aa185–287) of human NPM1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed):
Incubate antibody for 30 minutes at room temperature.
Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
NPM1 (Nucleophosmin 1, also known as B23, nutramin, NO38) is a ubiquitously expressed phosphoprotein involved in multiple cellular processes including:
- Ribosome assembly and transport
- Cytoplasmic/nuclear trafficking
- Regulation of DNA polymerase α activity
- Centrosome duplication
- Regulation of p53
NPM1 continuously shuttles between the nucleus, cytoplasm, and nucleolus, acting as a chaperone for core histones. It binds nucleic acids, prevents protein aggregation, protects enzymes from thermal denaturation, and assists in renaturation of denatured proteins.
It is associated with centrosome duplication and serves as a substrate for CDK2/cyclin E.
NPM1 is implicated in several tumor-associated translocations (e.g., NPM-ALK, NPM-RAR, NPM-MLF1) and may mediate oligomerization and oncogenic transformation.
Additionally, it sequesters the tumor suppressor RF in the nucleolus, preventing degradation until needed.
Dysfunction of NPM1 is linked to diseases such as acute myeloid leukemia and lymphomatoid papulosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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