Thermo Fisher Scientific STIM1 Recombinant Rabbit Monoclonal Antibody (1Z7E3)
STIM1 단백질을 인식하는 토끼 단클론 항체로, Western blot 및 ELISA에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, HEK293 세포에서 발현된 재조합 항체입니다. 고순도의 친화 크로마토그래피 정제 및 안정한 액상 형태로 제공됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 1Z7E3 |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 586–685 of human STIM1 (Q13586). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.34 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2912082 |
Product Specific Information
- Positive test controls: HeLa, BxPC-3, Mouse testis, Mouse brain, Rat testis
- Immunogen sequence:
LNHGLDKAHS LMELSPSAPP GGSPHLDSSR SHSPSSPDPD TPSPVGDSRA LQASRNTRIP HLAGKKAVAE EDNGSIGEET DSSPGRKKFP LKIFKKPLKK
Target Information
STIM1 (stromal interacting molecule; also known as GOK) acts as a sensor of calcium depletion within the endoplasmic reticulum and transduces the signal to Orai1, the presumptive CRAC channel at the plasma membrane. Following a decrease in luminal calcium concentration, STIM1 oligomerizes and induces Orai1 to enable entry of extracellular calcium into the cytoplasm. The precise mechanism of STIM1–Orai1 interaction has not yet been fully elucidated. STIM1 also associates with growing ends of microtubules and is involved in endoplasmic reticulum tubule extension.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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