Thermo Fisher Scientific Factor XIIIa Polyclonal Antibody
Factor XIIIa 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, WB, ELISA, IP에 사용 가능. 인간, 고양이, 생쥐, 비인간 영장류 반응성. 합성 펩타이드(AA 1-50) 면역원 사용, 친화 크로마토그래피 정제. 연구용 전용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Cat, Human, Mouse, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 1–50 on human Factor XIII A subunit protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The Factor XIII A subunit gene encodes a component of coagulation factor XIII, the final zymogen activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer of two A subunits (catalytic) and two B subunits (carrier). Platelet factor XIII consists of only two A subunits identical to plasma origin.
Upon thrombin cleavage and in the presence of calcium ions, plasma factor XIII releases its B subunits to form the active enzyme factor XIIIa, which functions as a transglutaminase. This enzyme catalyzes gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, stabilizing the fibrin clot, and also crosslinks alpha-2-plasmin inhibitor or fibronectin to fibrin alpha chains.
Deficiency of factor XIII is categorized as:
- Type I deficiency: Lack of both A and B subunits
- Type II deficiency: Lack of A subunit only
Such deficiencies can lead to prolonged bleeding, impaired wound healing, and recurrent miscarriage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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