Thermo Fisher Scientific Factor XIIIa Polyclonal Antibody
Factor XIIIa에 특이적인 Rabbit Polyclonal Antibody로, WB, ELISA, IP에 사용 가능. 인간, 고양이, 마우스, 영장류 반응성. 합성 펩타이드 항원 기반, 액상 형태로 -20°C 보관. 연구용으로 혈액 응고 관련 단백질 분석에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Cat, Human, Mouse, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 700–732 on human Factor XIII A subunit protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, while the B subunits serve as plasma carrier molecules. Platelet factor XIII consists only of 2 A subunits, identical to those of plasma origin. Upon cleavage by thrombin and in the presence of calcium ions, plasma factor XIII dissociates its B subunits to yield the active enzyme, factor XIIIa. This enzyme acts as a transglutaminase to catalyze gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor or fibronectin to the alpha chains of fibrin. Factor XIII deficiency can result in bleeding tendency, defective wound healing, and habitual abortion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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