Thermo Fisher Scientific CNTFR Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• In direct ELISAs, approximately 50% cross-reactivity with recombinant human CNTF sR alpha is observed.
• Reconstitute at 0.2 mg/mL in sterile PBS.
• Endotoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

Target Information

This gene encodes a hematopoietin/interferon-class receptor belonging to the cytokine receptor superfamily.
The encoded gene product represents the CNTF-specific alpha subunit of a heterotrimer forming the CNTF receptor complex, which also includes LIFR and gp130.
The receptor is membrane-attached via a glycosyl-phosphatidylinositol linkage and contains an immunoglobulin-like C2-type domain and a fibronectin type-III domain.
Signal transduction requires CNTF binding first to this alpha component, allowing recruitment of gp130 and LIFR beta to form the tripartite receptor complex.
This signaling stimulates gene expression, cell survival, or differentiation in various neuronal cell types.
Alternative splicing at this locus yields two variants encoding the same protein.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.