Thermo Fisher Scientific CD68 Monoclonal Antibody (OTI2B7), TrueMAB

Applications

• Western Blot (WB)

Tested Dilution

• 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional round of desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

CD68 (Macrosialin) is a 110 kDa integral membrane glycoprotein predominantly expressed on intracellular lysosomes of monocytes and macrophages, and to a lesser extent by dendritic cells and peripheral blood granulocytes.
It plays a role in phagocytic activities of tissue macrophages, involving both intracellular lysosomal metabolism and extracellular cell-cell or cell-pathogen interactions.
CD68 expression is observed in interdigitating reticulum cells in tonsil, histiocytic lymphoma, histiocytosis, acute myeloid leukemia (AML), and granulocytic sarcoma.
Elevated CD68 expression has been demonstrated on CD34+ cells in various human malignancies, including several AML studies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.