Thermo Fisher Scientific CD68 Monoclonal Antibody (OTI12B4), TrueMAB

Applications

• Western Blot (WB): 1:2,000
• Immunohistochemistry (Paraffin) (IHC (P)): Assay-Dependent

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using carrier-free antibody, perform an additional round of desalting (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

CD68 (Macrosialin) is a 110 kDa integral membrane glycoprotein predominantly expressed in intracellular lysosomes of monocytes and macrophages, and to a lesser extent in dendritic cells and peripheral blood granulocytes.
It plays a role in phagocytic activities of tissue macrophages, including intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions.
CD68 is expressed by interdigitating reticulum cells in tonsil and certain histiocytic lymphoma or histiocytosis, acute myeloid leukemia (AML), and granulocytic sarcoma.
Elevated expression of CD68 has been observed in CD34+ cells of various human malignancies, including several AML studies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.