Thermo Fisher Scientific beta Amyloid Recombinant Mouse Monoclonal Antibody (WO2)

Applications

Western Blot (WB)

• Tested Dilution: Assay-dependent

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: Assay-dependent

ELISA

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

Recognises amino acid residues 4–10 of human Amyloid Beta.

Target Information

Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer’s disease. Abeta peptide is 40–43 amino acids long and generated from the beta-amyloid precursor protein (beta APP) in a two-step process.
The first step involves cleavage of the extracellular, amino-terminal domain of beta APP by beta-secretase (BACE), which is synthesized as a propeptide and activated by furin. The mature BACE cleaves beta APP, producing a secreted fragment and a membrane-bound remnant.
Gamma-secretase then cleaves the remnant within the transmembrane region, generating the amyloid beta peptide. Gamma-secretase is a multi-subunit complex containing presenilin-1 and -2 as central components, and nicastrin as an associated glycoprotein that modulates peptide production.
Abeta forms extracellular filamentous deposits in amyloid cores and neuritic plaques, and is also found in neurofibrillary tangles.
Alzheimer’s disease, the most common cause of senile dementia, is characterized by abnormal filamentous protein deposits. Beta amyloid deposits are also detected in Lewy body dementia, Down’s syndrome, Dutch-type amyloidosis, cerebral amyloid angiopathy, and the Guam Parkinson-Dementia complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.