Thermo Fisher Scientific beta Amyloid Recombinant Mouse Monoclonal Antibody (WO2)
WO2 클론의 재조합 마우스 단일클론 항체로 인간 베타 아밀로이드(aa 1-42)를 인식. Western blot, IHC, ELISA 등 다양한 응용 가능. Protein A로 정제된 액상 형태, 1 mg/mL 농도. 알츠하이머병 연구용으로 적합.
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Applications
Western Blot (WB)
- Tested Dilution: Assay-dependent
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
ELISA
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | WO2 |
| Immunogen | Synthetic peptides corresponding to amino acids 1–42 of human beta amyloid, conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
Recognises amino acid residues 4–10 of human Amyloid Beta.
Target Information
Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer’s disease. Abeta peptide is 40–43 amino acids long and generated from the beta-amyloid precursor protein (beta APP) in a two-step process.
The first step involves cleavage of the extracellular, amino-terminal domain of beta APP by beta-secretase (BACE), which is synthesized as a propeptide and activated by furin. The mature BACE cleaves beta APP, producing a secreted fragment and a membrane-bound remnant.
Gamma-secretase then cleaves the remnant within the transmembrane region, generating the amyloid beta peptide. Gamma-secretase is a multi-subunit complex containing presenilin-1 and -2 as central components, and nicastrin as an associated glycoprotein that modulates peptide production.
Abeta forms extracellular filamentous deposits in amyloid cores and neuritic plaques, and is also found in neurofibrillary tangles.
Alzheimer’s disease, the most common cause of senile dementia, is characterized by abnormal filamentous protein deposits. Beta amyloid deposits are also detected in Lewy body dementia, Down’s syndrome, Dutch-type amyloidosis, cerebral amyloid angiopathy, and the Guam Parkinson-Dementia complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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