Thermo Fisher Scientific beta Amyloid Recombinant Mouse Monoclonal Antibody (6E10)
베타 아밀로이드(β-amyloid) 1-16 잔기 인식 마우스 단클론 항체로 알츠하이머 연구에 적합. WB, IHC, ELISA 등 다양한 분석에 사용 가능. HEK293 발현, Protein A 정제, 1 mg/mL 농도. 연구용 전용 제품.
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Thermo Fisher Scientific beta Amyloid Recombinant Mouse Monoclonal Antibody (6E10)
Applications and Tested Dilution
- Western Blot (WB): Assay-dependent
- Immunohistochemistry (IHC): Assay-dependent
- ELISA (ELISA): Assay-dependent
- Immunoprecipitation (IP): Assay-dependent
- Immunomicroscopy (IM): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 6E10 |
| Immunogen | Amyloid-beta peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody binds to amino acid residues 1–16 of beta amyloid.
Target Information
Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer’s disease. Abeta peptide (40–43 amino acids) is generated from the beta-amyloid precursor protein (beta APP) through a two-step enzymatic process involving beta-secretase (BACE) and gamma-secretase.
Gamma-secretase is a multi-subunit complex containing presenilin-1 and -2, with nicastrin acting as an associated transmembrane glycoprotein that modulates amyloid beta production.
Abeta forms extracellular filamentous deposits found in amyloid cores, neuritic plaques, and neurofibrillary tangles. Beta amyloid deposits are associated with Alzheimer’s disease, Lewy body dementia, Down’s syndrome, Dutch-type amyloidosis, cerebral amyloid angiopathy, and the Guam Parkinson-Dementia complex.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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