Thermo Fisher Scientific CD154 (CD40 Ligand) Recombinant Armenian Hamster Monoclonal Antibody (MR1)

Applications

Flow Cytometry (Flow)

• Tested Dilution: Assay-dependent

Functional Assay (Functional)

• Tested Dilution: Assay-dependent

Inhibition Assays (IA)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

This antibody is specific for murine CD40 ligand (CD40L), a 39 kDa transmembrane glycoprotein. CD40L is expressed transiently by activated T cells. Through its binding to CD40 on antigen presenting cells (APC) including B cells, monocytes/macrophages, and dendritic cells, it serves a crucial function in T cell-APC cognate interaction. CD40L interaction with CD40 transduces signals for T-dependent B cell activation and induces B cells to enter the cell cycle.

Target Information

CD40 Ligand (CD40-L), or CD154, is a membrane glycoprotein and differentiation antigen expressed on the surface of T cells. The CD40 Ligand stimulates B cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40 Ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T cells, accompanied by the production of IFN-gamma, TNF-alpha, and IL-2.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.