Thermo Fisher Scientific Phospho-JAK1 (Tyr1034) Polyclonal Antibody
JAK1 단백질의 Tyr1034 인산화 부위를 인식하는 폴리클로날 항체. Western blot, IHC, ICC/IF에 사용 가능. 사람, 생쥐, 랫트 반응성. PBS/glycerol 용액 형태로 제공되며, -20°C에서 보관.
- 카탈로그번호
- PA5104554
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:500 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human JAK1 (Accession P23458), corresponding to amino acid residues around phosphorylated Tyr1034. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816029 |
Product Specific Information
This antibody detects endogenous levels of JAK1 only when phosphorylated at Tyr1034, a site historically referenced as Tyr1022.
Target Information
Janus kinase 1 (JAK1) is a protein tyrosine kinase involved in interferon-alpha/beta and -gamma signal transduction pathways. Upon stimulation by interferons or cytokines, JAK1 recruits Stat transcription factors to cytokine receptor complexes. JAK1 then phosphorylates these Stat factors, enabling their dimerization and nuclear translocation, where they regulate gene transcription. Phosphorylation at tyrosine residues 1022 and 1023 is associated with catalytic activation of JAK1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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