Thermo Fisher Scientific Phospho-GSK3B (Ser9) Polyclonal Antibody
GSK3B 단백질의 Ser9 인산화 형태를 특이적으로 검출하는 polyclonal antibody. Western blot, IHC, ICC, IP 등 다양한 응용에 적합. 인간, 생쥐, 원숭이, 랫트 반응성. 고순도 정제 및 안정적 액상 형태로 제공.
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Thermo Fisher Scientific Phospho-GSK3B (Ser9) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Immunoprecipitation (IP) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GSK3B (Accession P49841), corresponding to amino acid residues around phosphorylated Ser9 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816030 |
Product Specific Information
This antibody detects endogenous levels of GSK3 beta only when phosphorylated at Serine 9.
Target Information
GSK3B (Glycogen Synthase Kinase 3 Beta) is a proline-directed serine/threonine protein kinase involved in energy metabolism, neuronal cell development, and body pattern formation. It negatively regulates glucose homeostasis and participates in inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways.
GSK3B is a critical component of the Wnt/β-catenin signaling pathway, inhibiting Wnt signaling by mediating β-catenin degradation. It also plays roles in Hedgehog, Notch, and insulin signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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