Thermo Fisher Scientific Alpha-1-Antitrypsin (SERPINA1) (Hepatocellular and Histiocytic Marker) Monoclonal Antibody (AAT/4571)
인간 SERPINA1 단백질을 인식하는 Mouse 모노클론 항체로, 간세포암 및 조직구종에서 양성 반응을 보임. IHC(P) 및 Peptide Array에 사용 가능. 200 µg/mL 농도의 액상형, Protein A/G 정제. 연구용으로만 사용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2c, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AAT/4571 |
| Immunogen | Recombinant fragment (around aa200–400) of human SERPINA1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Hepatocellular carcinoma or histiocytoma (IHC)
- Cellular Location: Cytoplasm
Target Information
Alpha-1-Antitrypsin (Alpha-1-AT) is synthesized in the liver and acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin—enzymes released during inflammatory reactions in the lung.
Deficiency of Alpha-1-AT leads to the digestion of pulmonary parenchyma and is associated with chronic obstructive lung disease (emphysema), hepatic cirrhosis in infants, and respiratory distress of the newborn.
Alpha-1-AT levels increase as an acute phase response to tissue necrosis and inflammation, and are elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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