Thermo Fisher Scientific Alpha-1-Antitrypsin (SERPINA1) (Hepatocellular and Histiocytic Marker) Monoclonal Antibody (AAT/4490)
인간 Alpha-1-Antitrypsin(SERPINA1)을 인식하는 mouse monoclonal antibody로, IHC(P) 및 Peptide Array에 사용 가능. 단백질 A/G로 정제된 액상 형태이며, 4°C에서 보관. 간세포암 및 조직구종 양성 대조군으로 활용 가능.
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카탈로그
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AAT/4490 |
| Immunogen | Recombinant fragment (around aa200–400) of human SERPINA1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Hepatocellular carcinoma or histiocytoma (IHC)
- Cellular Location: Cytoplasm
Target Information
Alpha-1-Antitrypsin (Alpha-1-AT) is synthesized in the liver and acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung.
In the absence of Alpha-1-AT, these enzymes are not inhibited and may digest pulmonary parenchyma.
Deficiency of Alpha-1-AT is associated with chronic obstructive lung disease (emphysema) and, less frequently, with hepatic cirrhosis in infants and respiratory distress of the newborn.
Increase in Alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation. Serum levels are elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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