Thermo Fisher Scientific Human C-Reactive Protein (CRP) Polyclonal Antibody, HRP

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Goats were immunized with purified human C-reactive Protein (CRP) derived from serum or plasma. The antiserum was solid-phase adsorbed to ensure specificity. The antibody was purified by antigen affinity chromatography using antigen coupled to agarose beads.

Target Information

C-reactive protein (CRP) is a major cyclic, pentameric acute-phase protein composed of five identical, noncovalently bound, nonglycosylated subunits. Each subunit consists of 206 amino acids with a molecular weight of approximately 24 kDa. CRP is synthesized by the liver and its plasma levels increase markedly during inflammatory processes.

CRP acts as an initiator of the classical complement cascade, binds to nuclear components such as chromatin and histones, and plays a crucial role in innate immunity. It mediates pre-immune nonspecific host defense mechanisms, showing a 100–1000 fold increase in response to injury, infection, or inflammation. CRP is opsonic, activates monocytes/macrophages, and functions as a scavenger during cell necrosis. Elevated basal levels of CRP are associated with increased risk of hypertension and cardiovascular diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.