Thermo Fisher Scientific Human C-Reactive Protein (CRP) Polyclonal Antibody, FITC

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:200 – 1:2,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:200 – 1:2,000

Product Specifications

Product Specific Information

Goats were immunized with purified human C-reactive Protein (CRP) of serum or plasma origin. Antiserum was solid-phase adsorbed to ensure specificity. The antibody was isolated by affinity chromatography using antigen coupled to agarose beads.

Target Information

C-reactive protein (CRP) is a major cyclic, pentameric acute phase protein composed of five identical, noncovalently bound, nonglycosylated subunits. Each subunit contains 206 amino acids with a molecular weight of 24 kDa.
CRP is synthesized by the liver and its plasma levels increase dramatically during inflammatory processes. It acts as an initiator of the classical complement cascade, binds nuclear components such as chromatin and histones, and plays an essential role in innate immunity and non-specific host resistance.
CRP levels can increase 100–1000 fold in response to injury, infection, or inflammation. It functions as an opsonin, activates monocytes/macrophages, and may act as a scavenger during cell necrosis. Elevated basal levels of CRP are associated with increased risk of hypertension and cardiovascular disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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