Thermo Fisher Scientific TET3 Monoclonal Antibody (OTI2F10), TrueMAB
인간 TET3 단백질(aa 241-568)을 인식하는 Mouse IgG1 단클론 항체. Western blot에 최적화(1:2000 희석). 동결건조 형태로 제공되며, PBS(pH 7.3, 8% trehalose) 버퍼에 재구성 가능. 연구용으로만 사용.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 241–568 of human TET3 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
TET3 is a member of the ten-eleven-translocation (TET) gene family and functions as a methylcytosine dioxygenase, converting methylcytosine to 5-hydroxymethylcytosine. It is highly expressed in hematopoietic cells. Unlike TET2, TET3 mutations have not been reported in myeloid malignancies.
TET3 is involved in DNA demethylation of zygotic DNA before the first mitosis and is implicated in epigenetic reprogramming of paternal DNA after fertilization. It may also contribute to somatic cell nuclear reprogramming during animal cloning.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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