Thermo Fisher Scientific RCAN2 Polyclonal Antibody
RCAN2 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot과 IHC에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며 항원 친화 크로마토그래피로 정제되었습니다. NIH-3T3 세포 용해물을 양성 대조군으로 권장합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 14 amino acid peptide near the center of human RCAN2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11155401 |
Product Specific Information
- A suggested positive control is NIH-3T3 cell lysate.
- PA5-20695 can be used with blocking peptide PEP-0810.
Target Information
Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus.
- Isoform 1: Expressed exclusively in the brain.
- Isoform 2: Ubiquitously expressed, highest in brain, heart, and muscle.
Both isoforms bind to the catalytic subunit of calcineurin, a Ca²⁺-dependent protein phosphatase involved in neuronal functions, and inhibit calcineurin’s activity.
Unlike isoform 1, isoform 2 expression is not induced by thyroid hormone T3.
RCAN2 belongs to a family of three endogenous calcineurin regulators located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting a role in this syndrome. Multiple isoforms of RCAN2 are known to exist.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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