Thermo Fisher Scientific MCM4 Polyclonal Antibody

Applications

Immunohistochemistry (IHC)

• Tested Dilution: 1:100–1:500

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with X. laevis, Bovine, Horse, Rabbit, Guinea pig, Orangutan, Monkey, Gorilla, Chimpanzee, and Gray short-tailed opossum.

Target Information

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) essential for the initiation of eukaryotic genome replication. The hexameric MCM complex is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and recruitment of other DNA replication-related proteins.
The MCM complex consisting of MCM4 with MCM2, 6, and 7 possesses DNA helicase activity and may act as a DNA unwinding enzyme. Phosphorylation by CDC2 kinase reduces DNA helicase activity and chromatin binding of the MCM complex. This gene is located on chromosome 8 adjacent to PRKDC/DNA-PK, a DNA-activated protein kinase involved in DNA double-strand break repair.
Alternatively spliced transcript variants encoding the same protein have been reported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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