Thermo Fisher Scientific MCM4 Polyclonal Antibody
Thermo Fisher Scientific의 MCM4 Polyclonal Antibody는 인간 및 생쥐 시료에 반응하는 Rabbit IgG 항체로, IHC 및 IHC(P) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 4°C에서 보관합니다. 연구용으로만 사용됩니다.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:100–1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 750 and 800 of human Minichromosome Maintenance 4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with X. laevis, Bovine, Horse, Rabbit, Guinea pig, Orangutan, Monkey, Gorilla, Chimpanzee, and Gray short-tailed opossum.
Target Information
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) essential for the initiation of eukaryotic genome replication. The hexameric MCM complex is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and recruitment of other DNA replication-related proteins.
The MCM complex consisting of MCM4 with MCM2, 6, and 7 possesses DNA helicase activity and may act as a DNA unwinding enzyme. Phosphorylation by CDC2 kinase reduces DNA helicase activity and chromatin binding of the MCM complex. This gene is located on chromosome 8 adjacent to PRKDC/DNA-PK, a DNA-activated protein kinase involved in DNA double-strand break repair.
Alternatively spliced transcript variants encoding the same protein have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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