Thermo Fisher Scientific DNA-PKcs Polyclonal Antibody
DNA-PKcs 폴리클로날 항체로 인간 시료에 반응하며, IHC 및 파라핀 절편 분석에 적합. 항원 친화 크로마토그래피로 정제된 액상 형태로 제공. 0.25 mg/mL 농도, 4°C 보관, 연구용 전용.
- 카탈로그번호
- IHC00044x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific DNA-PKcs Polyclonal Antibody
Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:100–1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 2100 and 2150 of human DNA-Dependent Protein Kinase, catalytic subunit |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Monkey, Northern white-cheeked gibbon, and Crab-eating macaque
Target Information
DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. It is an atypical kinase closely related to PI3 kinases and can be inhibited by small molecules targeting PI3 kinases.
DNA-PK encodes a component of the mediator complex, a transcriptional coactivator required for expression of most genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, potentially through interaction with RNA polymerase II and formation of the pre-initiation complex.
Multiple transcript variants encoding different isoforms have been identified for DNA-PK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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