Thermo Fisher Scientific TCF12 Monoclonal Antibody (OTI4D6), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

TCF12 (also known as HTF4) is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG.
It is expressed in various tissues including skeletal muscle, thymus, and B- and T-cells, and regulates lineage-specific gene expression through heterodimer formation with other bHLH E-proteins.
Together with E2A, TCF12 is essential for blocking thymocyte proliferation prior to pre-TCR expression and is critical for proper T cell differentiation.
Recent studies indicate TCF12 is also required for invariant natural killer T cell development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.