Thermo Fisher Scientific COL1A2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total Collagen I alpha 2.

Target Information

The COL1A2 gene encodes the pro-alpha2 chain of type I collagen, which forms a triple helix with two alpha1 chains and one alpha2 chain. Type I collagen is a fibril-forming collagen present in most connective tissues and abundant in bone, cornea, dermis, and tendon.
Mutations in this gene are linked to osteogenesis imperfecta types I–IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome.
Symptoms from COL1A2 mutations are generally less severe than those from COL1A1 mutations, reflecting distinct roles in matrix integrity. Three transcripts have been identified due to alternative polyadenylation signals.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.