Thermo Fisher Scientific MAPK8IP1 Monoclonal Antibody (OTI1D9), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, it is recommended to perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The MAPK8IP1 gene encodes a protein that regulates pancreatic beta-cell function. It is highly similar to mouse JIP-1, a regulator of c-Jun N-terminal kinase (MAPK8). This protein inhibits MAPK8-mediated activation of transcription factors and reduces IL-1β and MEKK1-induced apoptosis in pancreatic beta cells. It also acts as a DNA-binding transactivator of the glucose transporter GLUT2. REST (RE1-silencing transcription factor) represses its expression in insulin-secreting beta cells. Mutations in this gene have been associated with type 2 diabetes susceptibility.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.