Thermo Fisher Scientific LYVE1 Monoclonal Antibody (ALY7), eBioscience
Mouse LYVE-1 단백질을 인식하는 Rat IgG1 모노클로날 항체로, 흐름세포분석(Flow Cytometry)과 면역조직염색(IHC)에 적합. 비결합(Unconjugated) 형태이며 다양한 형광 및 비오틴 결합 옵션 제공. 0.5 mg/mL 농도, 4°C 보관.
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Thermo Fisher Scientific LYVE1 Monoclonal Antibody (ALY7), eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 1 publication |
| Immunohistochemistry (IHC) | - | View 30 publications |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | - | View 7 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-Dependent | View publications |
| Immunocytochemistry (ICC/IF) | Assay-Dependent | View 2 publications |
| Flow Cytometry (Flow) | 0.125 µg/Test | View 16 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ALY7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2864884 |
| Purity | >90% (SDS-PAGE) |
| Aggregation | <10% (HPLC) |
| Filtration | 0.2 µm post-manufacturing filtered |
Available Conjugated Formats
- Alexa Fluor 488
- Biotin
- eFluor 450
- eFluor 570
- eFluor 615
- eFluor 660
- PE
- PE-Cyanine7
- Request custom conjugation
Product Specific Information
The monoclonal antibody ALY7 recognizes mouse LYVE-1, a transmembrane glycoprotein similar to CD44. Its extracellular domain contains a conserved hyaluronan-binding region. LYVE-1 is expressed on lymphatic and liver endothelial cells and some macrophages.
The lymphatic system transports proteins and immune cells throughout the body. LYVE-1, along with podoplanin, PROX-1, Tie-2, and VEGFR-3, is a key marker of lymphatic endothelial cells. The ligand for LYVE-1 is hyaluronan, a large mucopolysaccharide. In vivo binding may require unmasking of glycan chains to expose the binding site.
Applications Reported:
- Flow cytometric analysis
- Immunohistologic staining of frozen tissue sections
Applications Tested:
- Flow cytometric analysis of transfected cell lines
- Immunofluorescent microscopy of mouse intestine cryosections
- ≤0.125 µg per 10⁶ cells (Flow)
- 2.5 µg/mL (Immunofluorescence)
- Antibody titration recommended for optimal assay performance.
Target Information
LYVE1 is a major receptor for hyaluronan (HA) on lymph vessel walls. It encodes a 322-residue type I integral membrane protein with a 212-residue extracellular domain containing a single Link module, similar to CD44.
Unlike CD44, LYVE1 localizes exclusively on lymph vessels, absent from blood vessels, making it a specific marker for lymphatic endothelium. It regulates leukocyte and tumor cell trafficking to lymph nodes.
Associated markers: LYVE1, PALE, VEGFR3, podoplanin
Related disease: Complete Androgen Insensitivity Syndrome
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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