Thermo Fisher Scientific CD20 (MS4A1) Monoclonal Antibody (UMAB39), UltraMAB
인간 CD20(MS4A1)을 인식하는 UMAB39 클론의 단클론 항체. IHC(P)에서 1:500 희석으로 검증됨. 액상 형태로 제공되며 PBS/BSA/glycerol 버퍼에 보관. B세포 표면 단백질 연구 및 항체 기반 B세포 분석에 적합.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB39 |
| Immunogen | Full length human recombinant protein of human MS4A1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD20 is a non-glycosylated surface phosphoprotein with a molecular weight of 33–37 kDa depending on phosphorylation.
It is expressed on mature and most malignant B cells, a subset of T lymphocytes, and follicular dendritic cells.
CD20 regulates transmembrane calcium conductance, cell cycle progression, and B-cell proliferation.
It associates with lipid rafts, and its interaction with the B-cell receptor (BCR) affects localization and signaling.
CD20 remains at the cell surface after antibody binding, making it a useful therapeutic target for B-cell depletion.
Diseases associated with CD20 dysfunction include MS4A1-related common variable immune deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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