Thermo Fisher Scientific ELL Monoclonal Antibody (OTI3E9), TrueMAB
Human ELL 단백질을 표적으로 하는 Mouse IgG1 단클론 항체로, Western blot에 최적화되어 있습니다. 무보존제, 동결건조 형태이며 PBS 및 trehalose 버퍼에 저장됩니다. RNA polymerase II/III 전사 관련 연구용으로 적합합니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3E9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 302–621 of human ELL produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
ELL is an elongation factor component of the super elongation complex (SEC), which enhances RNA polymerase II transcription by suppressing transient pausing along DNA.
It is also part of the little elongation complex (LEC), regulating snRNA gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780).
ELL plays an early role before SEC assembly by stabilizing RNA polymerase II recruitment and facilitating entry into the pause site, contributing to pre-initiation complex stability and early elongation.
[UniProt]
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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