Thermo Fisher Scientific SynGAP Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human SynGAP. Recombinant protein control fragment (Product #RP-95040). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SynGAP,uniProtId:Q96PV0-1,ncbiNodeId:9606,antigenRange:325-407,antigenLength:1343,antigenImageFileName:PA5-58362_SynGAP_Q96PV0-1_Rabbit.svg,antigenImageFileNamePDP:PA5-58362_SynGAP_Q96PV0-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2648134

Product Specific Information

Immunogen sequence: LHLYRDSDKK RKKDKAGYVG LVTVPVATLA GRHFTEQWYP VTLPTGSGGS GGMGSGGGGG SGGGSGGKGK GGCPAVRLKA RYQ

Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

Target Information

Synaptic Ras-GTPase activating protein (SynGAP) is a PDZ-domain interacting protein expressed almost exclusively in the brain. SynGAP has been shown to be a major component of postsynaptic density and associates with post synaptic density 95 kDa (PSD-95), a synaptic scaffold protein, and synaptic N-methyl-D-aspartate (NMDA) receptors. SynGAP Ras-GTPase activity has also been shown to be inhibited by phosphorylation by CaM kinase II, another abundant protein located in the postsynaptic density. It has been proposed that SynGAP may function as a negative regulator of MAP Kinase activation in the absence of active NMDA receptors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.