Thermo Fisher Scientific SUPV3L1 Polyclonal Antibody
SUPV3L1 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC, ICC/IF에 사용 가능. 인간 시료에 반응하며 항원 친화 크로마토그래피로 정제됨. PBS/glycerol 완충액에 보관되며 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SUPV3L1 (amino acids 428–515). Recombinant protein control fragment: Product #RP-97137 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS (pH 7.2) with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2648089 |
Product Specific Information
Immunogen sequence:
GMGLNLSIRR IIFYSLIKPS INEKGERELE PITTSQALQI AGRAGRFSSR FKEGEVTTMN HEDLSLLKEI LKRPVDPIRA AGLHPTAE
Antigen sequence identity:
- Mouse: 89%
- Rat: 91%
Target Information
SUPV3L1 is a major helicase involved in mitochondrial RNA metabolism. It forms part of the mitochondrial degradosome (mtEXO) complex, which degrades 3′ overhang double-stranded RNA in an ATP-dependent 3′-to-5′ direction.
It participates in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules. SUPV3L1 functions as an ATPase and multisubstrate helicase, unwinding dsDNA, dsRNA, and RNA/DNA hybrids in the 5′-to-3′ direction.
It plays a role in mitochondrial RNA surveillance, regulating mRNA stability and removal of aberrant transcripts, and is implicated in recombination and chromatin maintenance. The protein may also protect cells from apoptosis and associates with mitochondrial DNA. [UniProt]
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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