Thermo Fisher Scientific Protein APC Recombinant Rabbit Monoclonal Antibody (ARC0346)
Recombinant Rabbit Monoclonal Antibody targeting human APC protein. Validated for WB, ELISA, and IP applications. High specificity and affinity-purified. Supplied as a liquid in PBS with glycerol for stable long-term storage at -20°C.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| ELISA | 1 µg/mL |
| Immunoprecipitation (IP) | 0.5–4 µg antibody for 400–600 µg extracts |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0346 |
| Immunogen | Synthetic peptide corresponding to amino acids 1–100 of human APC (NP_0000292) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849092 |
Product Specific Information
Immunogen sequence:
MAAASYDQLL KQVEALKMEN SNLRQELEDN SNHLTKLETE ASNMKEVLKQ LQGSIEDEAM ASSGQIDLLE RLKELNLDSS NFPGVKLRSK MSLRSYGSRE
Target Information
The APC gene encodes a tumor suppressor protein that antagonizes the Wnt signaling pathway. It also participates in cell migration, adhesion, transcriptional activation, and apoptosis. Mutations in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant condition that often progresses to malignancy. Disease-associated mutations commonly cluster in the mutation cluster region (MCR), resulting in truncated protein products.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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