Thermo Fisher Scientific CD10 Recombinant Rabbit Monoclonal Antibody (6P8G4)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

6P8G4

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 52-750 of human CD10/MME (NP_0008932) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CD10,uniProtId:P08473-1,ncbiNodeId:9606,antigenRange:52-750,antigenLength:750,antigenImageFileName:MA5-35196_CD10_P08473-1_Rabbit.svg,antigenImageFileNamePDP:MA5-35196_CD10_P08473-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.05 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2849100

Product Specific Information

Immunogen sequence: YDDGICKSSD CIKSAARLIQ NMDATTEPCT DFFKYACGGW LKRNVIPETS SRYGNFDILR DELEVVLKDV LQEPKTEDIV AVQKAKALYR SCINESAIDS RGGEPLLKLL PDIYGWPVAT ENWEQKYGAS WTAEKAIAQL NSKYGKKVLI NLFVGTDDKN SVNHVIHIDQ PRLGLPSRDY YECTGIYKEA CTAYVDFMIS VARLIRQEER LPIDENQLAL EMNKVMELEK EIANATAKPE DRNDPMLLYN KMTLAQIQNN FSLEINGKPF SWLNFTNEIM STVNISITNE EDVVVYAPEY LTKLKPILTK YSARDLQNLM SWRFIMDLVS SLSRTYKESR NAFRKALYGT TSETATWRRC ANYVNGNMEN AVGRLYVEAA FAGESKHVVE DLIAQIREVF IQTLDDLTWM DAETKKRAEE KALAIKERIG YPDDIVSNDN KLNNEYLELN YKEDEYFENI IQNLKFSQSK QLKKLREKVD KDEWISGAAV VNAFYSSGRN QIVFPAGILQ PPFFSAQQSN SLNYGGIGMV IGHEITHGFD DNGRNFNKDG DLVDWWTQQS ASNFKEQSQC MVYQYGNFSW DLAGGQHLNG INTLGENIAD NGGLGQAYRA YQNYIKKNGE EKLLPGLDLN HKQLFFLNFA QVWCGTYRPE YAVNSIKTDV HSPGNFRIIG TLQNSAEFSE AFHCRKNSYM NPEKKCRVW

Target Information

CD10 (Common Acute Lymphocytic Leukemia Antigen, CALLA), is a cell surface enzyme with neutral metalloendopeptidase activity which inactivates a variety of biologically active peptides. CD10 is expressed on the cells of lymphoblastic, Burkitts, and follicular germinal center lymphomas, immature B cells with in adult bone marrow and on cells from patients with chronic myelocytic leukemia (CML). CD10 is also present on breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high expression on the brush border of kidney and gut epithelial cells. CD10 is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. Further, CD10 is a 100 kDa type II transmembrane glycoprotein that exists in a single copy of greater than 45 kb. The 5 untranslated region of the CD10 gene is alternatively spliced, resulting in four separate mRNA transcripts and the coding region is not affected by alternative splicing. Diseases associated with CD10 dysfunction include spinocerebellar ataxia 43 and Charcot-Marie tooth Disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.