Thermo Fisher Scientific PABPN1 Recombinant Rabbit Monoclonal Antibody (ARC0730)
PABPN1 단백질을 인식하는 토끼 리콤비넌트 단클론 항체. Western blot, IHC, ICC/IF, ELISA에 적합. 인간, 마우스, 랫트 반응성. HEK293 발현, Affinity Chromatography 정제. -20°C 보관, 연구용 전용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:6,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0730 |
| Immunogen | Synthetic peptide corresponding to amino acids 1–100 of human PABPN1 (Q86U42) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.19 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849089 |
Product Specific Information
Immunogen sequence:
MAAAAAAAAA AGAAGGRGSG PGRRRHLVPG AGGEAGEGAP GGAGDYGNGL ESEELEPEEL LLEPEPEPEP EEEPPRPRAP PGAPGPGPGS GAPGSQEEEE
Target Information
This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. It is required for progressive and efficient polymerization of poly(A) tails at the 3′ ends of eukaryotic transcripts and controls the size of the poly(A) tail (~250 nt). At steady-state, this protein is localized in the nucleus, whereas a different poly(A) binding protein is localized in the cytoplasm. Expansion of the GCG trinucleotide repeat (normally 6 copies to 8–13 copies) leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD). Related pseudogenes exist on chromosomes 19 and X, and read-through transcription occurs with the neighboring BCL2L2 gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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