Thermo Fisher Scientific Bcl-2 Monoclonal Antibody (2B11)
Bcl-2 단백질을 인식하는 mouse monoclonal antibody로, apoptosis 연구에 적합합니다. Western blot, ELISA, Immunoprecipitation 등에 사용 가능하며, HL-60 세포를 양성 대조군으로 권장합니다. -20°C 보관, Human 시료 검증됨.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| ELISA | Assay-dependent | 1 publication |
| Immunoprecipitation (IP) | 1 µL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2B11 |
| Immunogen | Recombinant human protein purified from E. coli (His-Bcl-2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_1954894 |
Product Specific Information
A suggested positive control for this product is HL-60 cells.
Target Information
BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. Members of the BCL-2 family can dimerize to modulate apoptosis. For example, Bag1 forms a heterodimer with BCL-2 to enhance its anti-apoptotic effect. Bax and Bak are critical for cytochrome c release from mitochondria, initiating apoptosis. Bax exerts a pro-apoptotic effect, whereas constitutive expression of BCL-2, such as translocation to the Ig heavy chain locus, is associated with follicular lymphoma. In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, while normal or hyperplastic germinal centers are negative. Two transcript variants of BCL-2 differ in their C-terminal ends. Overexpression of BCL-2 has been linked to human cancers, including B-cell lymphoma and prostate cancer.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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