Thermo Fisher Scientific PKR Polyclonal Antibody
Thermo Fisher Scientific의 PKR Polyclonal Antibody는 인간 PKR 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC, IP 등 다양한 응용에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 고농도 액상 형태로 제공됩니다. 바이러스 감염 및 세포 스트레스 연구에 유용합니다.
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Immunoprecipitation (IP) | 1:100–1:521 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human PKR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C for short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792815 |
Product Specific Information
- Keep as a concentrated solution.
- Predicted reactivity: Rhesus Monkey (83%), Chimpanzee (97%).
- Positive Control: MCF-7, MDA-MB-231.
- Centrifuge briefly prior to opening the vial.
Target Information
EIF2AK2 (PKR) is one of four kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to environmental stresses. PKR plays a critical role in antiviral defense through activation by double-stranded RNA produced during viral infection. It is involved in IFN-induced innate antiviral responses, virus-induced apoptosis, and regulation of cell growth and differentiation.
PKR induces apoptosis by upregulating Fas expression and mediates the FADD/Caspase-8 death signaling pathway. Upon viral infection, PKR functions as a dual protein, activating both cell survival and death pathways via kinase-independent and dependent mechanisms. It regulates multiple pathways, including NF-kappaB activation, p53, p38, and PDGF signaling. PKR has been implicated in tumor suppression, malignancy, and several neurodegenerative diseases such as Alzheimer’s, Huntington’s, and amyotrophic lateral sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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