Thermo Fisher Scientific Sclerostin Polyclonal Antibody
인간 Sclerostin 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보존됩니다. 골 형성 및 Wnt 신호 조절 연구에 유용합니다.
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Applications
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human Sclerostin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.73 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2792820 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (89%), Rat (92%), Rhesus Monkey (97%), Bovine (94%).
- Positive Control: HepG2 conditioned medium.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Sclerostin is a glycoprotein predominantly secreted by osteocytes and a member of the Cerberus/DAN family of BMP antagonists. It functions as an endogenous regulator of the canonical Wnt signaling pathway and bone homeostasis. Although mainly expressed by osteocytes, sclerostin is also present in bone, bone marrow, cartilage, kidney, and liver, and is produced by hypertrophic chondrocytes and cementocytes.
Sclerostin interacts with LRP5, LRP6, and LRP4 to inhibit Wnt signaling and can promote osteoclast activity by increasing RANKL expression in osteocytes. Its physiological importance is highlighted by bone dysplasia disorders such as sclerosteosis and van Buchem disease, caused by mutations leading to reduced sclerostin levels and excessive bone formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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