Thermo Fisher Scientific SQSTM1 Polyclonal Antibody
Human SQSTM1 단백질을 인식하는 sheep polyclonal antibody로, WB 및 IHC(F/P) 실험에 적합합니다. 합성 펩타이드(aa 300-360)를 항원으로 제작되었으며, PBS buffer에 보관됩니다. 연구용으로 NF-κB 신호전달 관련 단백질 분석에 활용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 10–50 µg/mL | - |
| Immunohistochemistry (Frozen) (IHC (F)) | 10–50 µg/mL | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 300–360 of human SQSTM1 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: Sequestosome-1.
Target Information
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-κB) signaling pathway. It acts as a scaffolding/adaptor protein with TNF receptor-associated factor 6 to mediate NF-κB activation in response to upstream signals.
Alternatively spliced transcript variants encoding either the same or different isoforms have been identified.
Mutations in this gene are associated with sporadic and familial Paget disease of bone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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