Thermo Fisher Scientific Sortilin Polyclonal Antibody
Sortilin 단백질을 인식하는 Rabbit Polyclonal Antibody로 인간 시료에 반응함. Western blot 및 IHC에 적합하며, Lyophilized 형태로 제공됨. 장기 보관 시 -20°C에서 안정적으로 유지 가능. 연구용으로만 사용.
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Thermo Fisher Scientific Sortilin Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:3,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:3,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the cytoplasmic domain of human Sortilin conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: Sortilin.
Target Information
Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface.
It is required for protein transport from the Golgi apparatus to lysosomes via a pathway independent of the mannose-6-phosphate receptor (M6PR), and also for transport to endosomes.
Sortilin promotes neuronal apoptosis by mediating endocytosis of proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB).
Additionally, Sortilin acts as a receptor for neurotensin.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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