Thermo Fisher Scientific STAM1, 2 Polyclonal Antibody
STAM1 및 STAM2 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot과 IHC에 적합합니다. 인간, 마우스, 랫드 등 다양한 종에 반응하며, 합성 펩타이드 면역원으로 제작되었습니다. 연구용으로 세포 신호전달 및 단백질 상호작용 분석에 활용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5,000 |
| Immunohistochemistry (IHC) | 1:5,000 |
| Miscellaneous PubMed (Misc) | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from human STAM 1, 2 (STAM-1, STAM-2) conjugated to blue carrier protein was used as the antigen |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage buffer | Whole serum |
| Contains | No preservative |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
- The peptide is homologous in many species including rat, mouse, zebra fish, and xenopus.
- Specificity: STAM1 and STAM2.
Target Information
STAM1
STAM1 is involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSF stimulation, it plays a role in signaling leading to DNA synthesis and c-myc induction. It may also play a role in endocytic trafficking and T-cell development.
- Subunit: Heterodimer composed of STAM1 and HGS/HRS; interacts directly with STAMBP/AMSH.
- Tissue Specificity: Ubiquitously expressed.
STAM2
STAM2 is also involved in intracellular signal transduction mediated by cytokines and growth factors. It likely acts via association with ubiquitinated cargo proteins on early endosomes, participating in sorting for lysosomal trafficking. Upon IL-2 and GM-CSF stimulation, it contributes to DNA synthesis and c-myc induction and may play a role in T-cell development.
- Subunit: Heterodimer or heterotrimer composed of STAM2 and HGS/Hrs; EPS15 can be part of the complex.
- Interactions: Interacts with STAMBP/AMSH, JAK2, JAK3, ubiquitinated proteins, USP8/UBPY, CBX5, and VPS37C.
- Tissue Specificity: Ubiquitously expressed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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