Thermo Fisher Scientific SQSTM1 Polyclonal Antibody
SQSTM1 단백질을 타겟으로 하는 Rabbit Polyclonal Antibody로, Western blot 및 Immunohistochemistry에 적합합니다. 인간 시료 반응성이 있으며, PBS 기반으로 보존됩니다. 연구용으로 사용되며 NF-κB 신호전달 경로 관련 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 10–50 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 10–50 µg/mL |
| Immunohistochemistry (Frozen) (IHC-F) | 10–50 µg/mL |
| Miscellaneous PubMed (Misc) | – |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 300–360 of human SQSTM1 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: Sequestosome-1.
Target Information
The SQSTM1 gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-κB) signaling pathway.
This protein acts as a scaffolding/adaptor molecule with TNF receptor-associated factor 6 to mediate NF-κB activation in response to upstream signals.
Alternatively spliced transcript variants encoding similar or distinct isoforms have been identified.
Mutations in this gene are associated with sporadic and familial Paget disease of bone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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