Thermo Fisher Scientific beta Catenin Polyclonal Antibody
Human beta-catenin 단백질을 인식하는 염소 유래 다클론 항체로, WB, ICC/IF, Flow Cytometry에 사용 가능. 비결합형 액상 형태이며 0.5 mg/mL 농도. 세포 접착 및 신호전달 연구에 적합.
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Thermo Fisher Scientific beta Catenin Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.3 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence: ETARCTAGTLHNLS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933832 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
Beta-catenin is an adherens junction (AJ) protein involved in cell-cell adhesion and epithelial layer maintenance. It interacts with E-cadherin and alpha-catenin, linking adhesion complexes to the actin cytoskeleton. Beta-catenin also associates with signaling pathways including Wnt/Wingless, tyrosine kinases, and phosphatases, influencing morphogenesis and tumorigenesis. It is expressed in various hair follicle cells and has pathological roles in pilomatrixoma, medulloblastoma, colorectal and ovarian cancers, and other solid tumors. In the nucleus, beta-catenin coactivates Lef/Tcf transcription factors, promoting expression of cyclin D and c-myc, key regulators of cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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