Thermo Fisher Scientific beta Catenin Polyclonal Antibody
Thermo Fisher Scientific의 beta Catenin Polyclonal Antibody는 인간 베타카테닌 단백질을 인식하는 염소 유래 IgG 항체입니다. Western blot, IHC, ICC/IF 등 다양한 응용에 적합하며, 고순도의 액상 형태로 제공됩니다. 세포 접착 및 신호전달 연구용으로 최적화된 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.3–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-QIPSTQFDAAHPTN (aa 108–121) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933833 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
Beta-catenin is an adherens junction (AJ) protein involved in cell-cell adhesion and signaling. It interacts with E-cadherin and alpha-catenin, linking adhesion complexes to the actin cytoskeleton. Beta-catenin also associates with adenomatous polyposis coli protein and microtubules, participating in Wnt/Wingless and other signaling pathways that regulate morphogenesis and cell proliferation. Dysregulation of beta-catenin is implicated in various cancers, including colorectal, ovarian, breast, and skin tumors. In the nucleus, beta-catenin co-activates Lef/Tcf transcription factors, promoting expression of genes such as cyclin D and c-myc.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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