Thermo Fisher Scientific Ataxin 3 Recombinant Superclonal Antibody (13HCLC)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific.
They combine multiple recombinant monoclonal antibodies to achieve both the sensitivity of polyclonal antibodies and the specificity of monoclonal antibodies, with the consistency of recombinant production.

• Recognizes multiple epitope sites on the target
• Provides higher detection sensitivity for low-abundance targets
• Each lot is reproducible due to known light and heavy chain composition
• Formerly called “Recombinant polyclonal antibody”, now rebranded as “Recombinant Superclonal™ antibody”
• Physical product and performance remain unchanged

Target Information

Machado-Joseph disease (MJD), also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder.
The disease is caused by an expansion of (CAG)n repeats in the Ataxin-3 coding region (from normal 13–36 to 68–79 repeats).
There is a negative correlation between age of onset and CAG repeat number.

Ataxin-3 protein interacts with transcriptional regulators (CBP, p300, PCAF), represses transcription, and functions as a histone-binding deubiquitinating enzyme.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.