Thermo Fisher Scientific NTRK2 Monoclonal Antibody (OTI2E1), TrueMAB
인간 NTRK2(TrkB) 단백질을 인식하는 Mouse monoclonal 항체로, WB, IHC(P), ICC/IF에 사용 가능. 동결건조 형태로 제공되며, 재구성 후 약 1 mg/mL 농도로 사용. 신경계 발달 및 시냅스 기능 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2E1 |
| Immunogen | Full-length protein expressed in 293T cell transfected with human NTRK2 expression vector |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
NTRK2 (TRKB) encodes a receptor belonging to the neurotrophic factor family, essential for the development and maintenance of the mammalian nervous system.
It serves as the receptor for brain-derived neurotrophic factor (BDNF), regulating short-term synaptic functions and long-term potentiation of brain synapses.
TrkB is a membrane-bound tyrosine kinase involved in neural differentiation and signaling via the MAPK pathway.
Mutations in the TrkB gene are associated with obesity and mood disorders.
Alternative splice variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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