Thermo Fisher Scientific FSTL1 Monoclonal Antibody (12)

Applications

ELISA (ELISA)

• Tested Dilution: 1:1,000–1:2,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Rat FSTL1.

Target Information

Follistatin-like protein 1 (FSTL1) is a widely expressed extracellular glycoprotein belonging to the osteonectin (BM-40/SPARC) family. It contains a follistatin-like and an extracellular calcium-binding domain.
Initially identified as a TGF-beta-inducible protein in mouse osteoblasts, FSTL1 is involved in various cellular functions such as proliferation, differentiation, apoptosis, and migration. It also participates in biological processes including embryonic development, inflammation, angiogenesis, tumorigenesis, and immune disease pathogenesis.
FSTL1 is highly conserved across mammals and widely expressed in human tissues. It can be upregulated by innate immune signaling mediators (e.g., TLR4 agonists, IL-1β) via NF-κB pathways to induce pro-inflammatory cytokines such as TNF-α, IL-1β, IL-6, and IL-8.
While mesenchymal cells produce FSTL1, it is absent in hematopoietic cells under normal conditions. However, macrophages and monocytes can uptake FSTL1 at inflammation sites, leading to caspase-1 activation and IL-1β maturation.
Overexpression of FSTL1 contributes to immune diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA), whereas reduced serum levels are linked to ovarian and endometrial carcinogenesis, influencing cell proliferation, migration, and invasion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.