Thermo Fisher Scientific Phospho-SREBP1 (Ser338) Polyclonal Antibody
SREBP1의 Ser338 인산화 상태를 인식하는 rabbit polyclonal antibody. Western blot, IHC, ICC/IF에 적합하며 사람, 마우스, 랫트 시료에 반응. 1 mg/mL 액상 형태로 제공되며, -20°C에서 보관. 연구용으로만 사용 가능.
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- PA5105567
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SREBF1 (Accession P36956), corresponding to amino acid residues around phosphorylated Ser338. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816995 |
Product Specific Information
This antibody detects endogenous levels of SREBP1 only when phosphorylated at Ser338.
Target Information
Sterol regulatory element-binding proteins (SREBPs) are transcription factors belonging to the basic helix-loop-helix leucine zipper family of DNA-binding proteins. Three isoforms (SREBP-1a, SREBP-1c, and SREBP-2) have been identified in mammalian tissues, differing in structure, regulation, and function.
SREBP-1a and SREBP-1c are products of alternative promoter usage of the SREBP-1 gene, while SREBP-2 is transcribed from a separate gene. SREBPs exist as 120 kDa inactive precursors in the endoplasmic reticulum (ER) membrane. Upon activation, SREBP translocates to the Golgi, where proteolytic cleavage produces a mature 60–78 kDa transcriptionally active fragment.
In liver and adipose tissues, SREBPs regulate lipid and cholesterol metabolism by inducing transcription of related genes. SREBP-1 primarily influences triglyceride synthesis and accumulation, whereas SREBP-2 is more closely associated with cholesterol synthesis and accumulation.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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