Thermo Fisher Scientific Phospho-MYH9 (Tyr754) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Antibody detects endogenous levels of MYH9 only when phosphorylated at Tyr754.

Target Information

The MYH9 gene, located on chromosome 22q12.3, encodes the heavy chain of non-muscle myosin IIA (NMHC IIA), a critical component of the actin cytoskeleton that plays essential roles in various cellular processes. Structurally, the MYH9 gene spans over 106 kilobases and includes 41 exons that translate into a protein of 1,960 amino acids. This protein is part of a hexameric complex composed of two heavy chains, two regulatory light chains, and two essential light chains.

The NMHC IIA protein interacts with actin filaments and is involved in cellular activities such as:

• Cell migration
• Adhesion
• Division
• Maintenance of cell shape

Mutations in MYH9 can result in MYH9-related diseases (MYH9-RD), including:

• May-Hegglin anomaly
• Fechtner syndrome
• Epstein syndrome

These disorders feature macrothrombocytopenia (abnormally large platelets) and may lead to hearing loss, renal failure, and cataracts later in life. MYH9 also plays a crucial role in hematopoiesis, necessary for the survival and maintenance of hematopoietic stem and progenitor cells (HSPCs). Loss of MYH9 function disrupts normal hematopoiesis, leading to severe blood cell deficiencies and bone marrow failure.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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