Thermo Fisher Scientific Phospho-ATM (Ser1981) Polyclonal Antibody
ATM 단백질의 Ser1981 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot에 적합하며 인간 및 마우스 시료에서 반응. DNA 손상 반응 및 세포주기 연구에 유용. 액상 형태로 제공되며 -20°C에서 보관.
- 카탈로그번호
- PA5105953
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ATM (Accession Q13315), corresponding to amino acid residues around phosphorylated Ser1981 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817352 |
Product Specific Information
This antibody detects endogenous levels of ATM only when phosphorylated at Ser1981.
Target Information
Ataxia-telangiectasia Mutated (ATM) belongs to the PI3/PI4 kinase family. Mutations in ATM cause ataxia-telangiectasia, a rare autosomal recessive disorder characterized by neurodegeneration, immune deficiency, and increased cancer risk. ATM functions as a serine/threonine kinase that phosphorylates several key regulators of the cell cycle, including P53, Mdm2, BRCA1, and SMC1. It plays a central role in the repair of double-stranded DNA breaks caused by ionizing radiation and other mutagens. Upon DNA damage, ATM is autophosphorylated at Ser1981, activating downstream kinase cascades involved in cell cycle control, apoptosis, and DNA repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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