Thermo Fisher Scientific QKI Monoclonal Antibody (N147/6), FITC

Thermo Fisher Scientific QKI Monoclonal Antibody (N147/6), FITC

Applications and Tested Dilution

Product Specifications

Additional Formats

• Unconjugated (MA5-27651)
• APC (MA5-45689)
• PE (MA5-45692)
• PerCP (MA5-45691)
• Request custom conjugation (Custom Form)

Product Specific Information

Mouse: 100% identity (341/341 amino acids identical).
Rat: 99% identity (339/341 amino acids identical).

90% identity with QKI-6, QKI-7, and QKI-7b.

1 µg/mL of MA5-45690 was sufficient for detection of Pan-QKI in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Detects approximately 36–38 kDa.
This antibody was formerly sold as clone S147-6.

Target Information

This gene encodes the sacsin protein, which includes a UbL domain at the N-terminus, a DnaJ domain, and a HEPN domain at the C-terminus. The gene is highly expressed in the central nervous system, also found in skin, skeletal muscles, and at low levels in the pancreas. Mutations in this gene result in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS). Sacsin protects against mutant ataxin-1. A pseudogene associated with this gene is located on chromosome 11. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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