Thermo Fisher Scientific QKI Monoclonal Antibody (N147/6), PE
QKI 단백질을 검출하기 위한 Thermo Fisher Scientific의 Mouse 모노클로날 항체로, PE 형광 표지된 제품입니다. WB, IHC, ICC/IF에 사용 가능하며 Human, Mouse, Rat에 반응합니다. 고순도 Protein G 정제, 4°C 보관, 연구용 전용입니다.
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Thermo Fisher Scientific QKI Monoclonal Antibody (N147/6), PE
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N147/6 |
| Immunogen | Fusion protein amino acids 1–341 (full-length) of human QKI-5 |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2932146 |
Additional Formats
- Unconjugated (MA5-27651)
- APC (MA5-45689)
- FITC (MA5-45690)
- PerCP (MA5-45691)
- Request custom conjugation
Product Specific Information
- Mouse: 100% identity (341/341 amino acids identical)
- Rat: 99% identity (339/341 amino acids identical)
90% identity with QKI-6, QKI-7, and QKI-7b
- 1 µg/mL of MA5-45692 detects Pan-QKI in 20 µg of rat brain lysate by colorimetric immunoblot using Goat anti-mouse IgG:HRP as secondary antibody
- Detects approximately 36–38 kDa
- Formerly sold as clone S147-6
Target Information
This gene encodes the sacsin protein, which includes a UbL domain at the N-terminus, a DnaJ domain, and a HEPN domain at the C-terminus. It is highly expressed in the central nervous system, also found in skin, skeletal muscle, and at low levels in the pancreas. Mutations in this gene result in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), a neurodegenerative disorder characterized by early-onset cerebellar ataxia with spasticity and peripheral neuropathy. Sacsin protects against mutant ataxin-1. A pseudogene is located on chromosome 11. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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